Hmm, sure i'll bite... I'm sure someone will pull the "You drank from the superhuman punch bowl! HAR HAR HAR!" XD
My faction utilizes a sort of trans human pilots, they're not robots or anything, but a small percentage of the Varangian Guard went through a process that I called AGE (Augmented Genetic Enhancement). The procedure and results are literally and shamelessly ripped from the Jason Bourne films minus the behavioral modifications (if you've seen it is saves me a long winded explanation, in short they aren't space marines or anything, they get better physical and mental attributes, but within the confides of human capacity). Regardless it comes with a cost, around the time the applicants hit 50, their bodies rapidly begin to degrade, they age faster, grow weak, succumb to illness until they ultimately give out and die, usually no more than 3 to 4 years later. The change also needs to be maintained with drugs, all provided by their employers Valhallan Industries, which binds them to a lifetime contract. There are no side effects from the drugs though the enhancements will fade without them and the degeneration will happen sooner. It's a very effective procedure, besides being obscenely illegal under Solar Union humanitarian laws and the whole YOUR GONNA DIE AT 50 bit...
Outside of that I have another shameless rip of the from Gundam Wing planned for a frame in the future (The ). It was designed to fight a bonded ijad/human pilot whose frame utilizes both of their consciousnesses for improved combat effectiveness (i.e. reaction time, pain suppression, etc.) Unlike the Gundam version where people "learn" to control it, my version is also suppressed via cognitive enhancing drugs. Yeah it's more drugs but Valhallan did make it's second fortune through pharmaceutical research and development, so they stick to their strengths.
I came from the bottom, now I made it to the top. Newtype flow I'm the hottest on the block. Somebody tell these haters that I'm never gonna stop. Till I kill em all like a colony drop. I'm yellin out Sieg Zeon, Sieg Zeon